New Opportunities in the Synthesis of Monastrol

Abstract

The synthesis of eutectic mixtures based on 3- (carboxymethyl) -1-vinyl-1H-imidazole-3-ium (chloride, bromide, hexofluorophosphate) and thiourea in various ratios (from 2: 1 to 1: 3) was realized, the aggregate state and established catalytic activity for the synthesis of Monastrol, which showed a wide range of pharmacological activity. Recently, interest in the significance of dihydropyrimidines has attracted great interest. Dihydropyrimidines occupy a key place in various biological processes of various body structures that carry vital information. The most effective method currently used for the synthesis of dihydropyrimidines remains the well-studied multicomponent Biginelli reaction. The Biginelli reaction, which is commonly used for the direct preparation of Monastrol and its derivatives, has many advantages over traditional synthetic methods.