Hematological and Polarimetric Differentiation of Benign and Malignant Cervical Cancer under the Influence of Moringa Oleifera

Abstract

This study investigates the comparative effects of Moringa Oleifera supplementation on hematological profiles and optical polarization properties in benign and malignant cervical cancer cases. Blood samples and cervical tissues were collected from histopathologically confirmed benign (n=15) and malignant (n=15) cervical cancer patients. Hematological parameters including WBC, RBC, hemoglobin (Hb), hematocrit (HCT), and platelet counts were analyzed before and after Moringa treatment (500 mg/day for 30 days). Polarimetric analysis was performed using Mueller matrix decomposition and Poincaré sphere representation to evaluate tissue birefringence and depolarization properties at 450 nm. Results revealed a significant improvement in hematological indices post-Moringa intervention, with marked increases in HGB (benign: 11.2→12.7 g/dL; malignant: 10.1→11.3 g/dL) and RBC count (benign: 4.1→4.7×10⁶/μL; malignant: 3.8→4.3×10⁶/μL). WBC levels showed a downward trend in malignant cases, suggesting immunomodulatory effects. Polarimetric outcomes demonstrated increased linear retardance in benign tissues (Δδ = +0.15 rad) and reduced depolarization in malignant samples (ΔΔ = -0.09), indicating structural modulation under Moringa influence. The combined hematological and polarimetric data suggest that Moringa oleifera may offer supportive benefits in managing cervical cancer progression, with notable distinctions in response between benign and malignant conditions. These findings highlight the potential of integrating optical and hematological biomarkers in cancer monitoring.