A Controlled Clinical Study on Efficacy and Safety of Qi-Zhi-YiShen Formula in Treating Qi Deficiency and Blood Stasis Syndromein Chronic Glomerulonephritis

Authors

  • Dapeng Wang College of Integrated Traditional Chinese and Western Medicine, Dalian Medical University, Liaoning Dalian 116044, China Author
  • Maomao Wu College of Integrated Traditional Chinese and Western Medicine, Dalian Medical University, Liaoning Dalian 116044, China Author
  • Xiangbo Qi College of Integrated Traditional Chinese and Western Medicine, Dalian Medical University, Liaoning Dalian 116044, China Author
  • Shuwei Ren College of Integrated Traditional Chinese and Western Medicine, Dalian Medical University, Liaoning Dalian 116044, China Author
  • Zewen Yan College of Integrated Traditional Chinese and Western Medicine, Dalian Medical University, Liaoning Dalian 116044, China Author
  • Qingnan Zhu College of Integrated Traditional Chinese and Western Medicine, Dalian Medical University, Liaoning Dalian 116044, China Author
  • Qingsi Wen College of Integrated Traditional Chinese and Western Medicine, Dalian Medical University, Liaoning Dalian 116044, China Author
  • Yan Shi College of Integrated Traditional Chinese and Western Medicine, Dalian Medical University, Liaoning Dalian 116044, China Author
  • Yuye Li College of Integrated Traditional Chinese and Western Medicine, Dalian Medical University, Liaoning Dalian 116044, China Author
  • Yu Sun College of Integrated Traditional Chinese and Western Medicine, Dalian Medical University, Liaoning Dalian 116044, China Author
  • Jianguo Xie College of Integrated Traditional Chinese and Western Medicine, Dalian Medical University, Liaoning Dalian 116044, China Author

DOI:

https://doi.org/10.47363/JTMCM/2025(3)126

Keywords:

Chronic Glomerulonephritis, Qi-Zhi-Yi-Shen Formula, Clinical Efficacy Observation

Abstract

Objective
Evaluate the clinical efficacy and safety of Qi-Zhi-Yi-Shen Formula in treating qi deficiency and blood stasis syndrome in chronic glomerulonephritis (CGN)

Methods
The clinical study included 48 patients with qi deficiency and blood stasis type chronic glomerulonephritis, who were divided into an experimental group and a control group based on actual conditions and patient willingness, receiving treatment for 8 weeks. Both groups underwent routine basic treatment; the control group received conventional treatment supplemented with Irbesartan tablets, while the experimental group additionally received modified Qi-Zhi-Yi-Shen Formula. Relevant indicator data were collected to assess changes in urinary protein quantification, kidney function indicators, urinary red blood cell count, and traditional Chinese medicine syndrome scores before and after treatment. Statistical analysis of all data was performed using SPSS software to compare the differences in results within and between groups before and after treatment.

Results
Before treatment, the basic information and various indicators of both groups were comparable (P > 0.05). After treatment, comparisons showed: ① 24-hour urinary protein quantification: both groups showed significant improvement (P < 0.05), with the experimental group outperforming the control group (P < 0.05). ② Urinary red blood cell count: both groups improved compared to before (P < 0.05), with the experimental group outperforming the control group (P < 0.05). ③ Creatinine: both groups had lower creatinine levels compared to before (P < 0.05), with the experimental group outperforming the control group (P < 0.05). ④ Traditional Chinese medicine syndrome scores: both groups showed a decrease (P < 0.05), with the experimental group outperforming the control group (P < 0.05). ⑤ Overall efficacy comparison: the total effective rate of the experimental group was 95.8%, while that of the control group was 83.3%. ⑥ Comparison of traditional Chinese medicine syndrome efficacy: the effective rate of the experimental group was 95.8%, while that of the control group was 83.3%. No abnormal blood potassium levels or liver function damage occurred during treatment

Conclusion
The application of Qi-zhi-Yi-shen Formula on the basis of conventional Western medicine treatment can significantly improve the traditional Chinese medicine syndrome scores, kidney function indicators, urinary protein quantification, and urinary red blood cell count in patients with chronic glomerulonephritis, with good safety.

Author Biographies

  • Dapeng Wang, College of Integrated Traditional Chinese and Western Medicine, Dalian Medical University, Liaoning Dalian 116044, China

    College of Integrated Traditional Chinese and Western Medicine, Dalian Medical University, Liaoning Dalian 116044, China

  • Maomao Wu, College of Integrated Traditional Chinese and Western Medicine, Dalian Medical University, Liaoning Dalian 116044, China

    College of Integrated Traditional Chinese and Western Medicine, Dalian Medical University, Liaoning Dalian 116044, China

  • Xiangbo Qi, College of Integrated Traditional Chinese and Western Medicine, Dalian Medical University, Liaoning Dalian 116044, China

    College of Integrated Traditional Chinese and Western Medicine, Dalian Medical University, Liaoning Dalian 116044, China

  • Shuwei Ren, College of Integrated Traditional Chinese and Western Medicine, Dalian Medical University, Liaoning Dalian 116044, China

    College of Integrated Traditional Chinese and Western Medicine, Dalian Medical University, Liaoning Dalian 116044, China

  • Zewen Yan, College of Integrated Traditional Chinese and Western Medicine, Dalian Medical University, Liaoning Dalian 116044, China

    College of Integrated Traditional Chinese and Western Medicine, Dalian Medical University, Liaoning Dalian 116044, China

  • Qingnan Zhu, College of Integrated Traditional Chinese and Western Medicine, Dalian Medical University, Liaoning Dalian 116044, China

    College of Integrated Traditional Chinese and Western Medicine, Dalian Medical University, Liaoning Dalian 116044, China

  • Qingsi Wen, College of Integrated Traditional Chinese and Western Medicine, Dalian Medical University, Liaoning Dalian 116044, China

    College of Integrated Traditional Chinese and Western Medicine, Dalian Medical University, Liaoning Dalian 116044, China

  • Yan Shi, College of Integrated Traditional Chinese and Western Medicine, Dalian Medical University, Liaoning Dalian 116044, China

    College of Integrated Traditional Chinese and Western Medicine, Dalian Medical University, Liaoning Dalian 116044, China

  • Yuye Li, College of Integrated Traditional Chinese and Western Medicine, Dalian Medical University, Liaoning Dalian 116044, China

    College of Integrated Traditional Chinese and Western Medicine, Dalian Medical University, Liaoning Dalian 116044, China

  • Yu Sun, College of Integrated Traditional Chinese and Western Medicine, Dalian Medical University, Liaoning Dalian 116044, China

    College of Integrated Traditional Chinese and Western Medicine, Dalian Medical University, Liaoning Dalian 116044, China

  • Jianguo Xie, College of Integrated Traditional Chinese and Western Medicine, Dalian Medical University, Liaoning Dalian 116044, China

    College of Integrated Traditional Chinese and Western Medicine, Dalian Medical University, Liaoning Dalian 116044, China

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Published

2025-07-25

Issue

Vol. 3 No. 3 (2025): Volume 3 Issue 3

Section

Articles