Metastatic Associated Fibroblast (MAF): is it a Key Driver of Tumour Metastasis in Oral Cancer

Authors

  • Subramania Iyer Prof &Head of Dept, Head and Neck Oncology, Amrita Vishwa Vidyapeetham, Amrita Institute of Medical Sciences Kochi, India. Author
  • Rajalakshmi G DHR Fellow/Scientist Head and Neck Oncology, Amrita Vishwa Vidyapeetham, Amrita Institute of Medical Sciences Kochi, India. Author
  • Mahija Janardhanan Professor, Dept of Oral Pathology Amrita Vishwa Vidyapeetham, Amrita School of Dentistry Kochi, India. Author
  • Krishna Kumar Thankappan Professor, Head and Neck Oncology, Amrita Vishwa Vidyapeetham, Amrita Institute of Medical Sciences Kochi, India. Author

DOI:

https://doi.org/10.47363/JCRR/2024(6)203

Keywords:

Metastatic Associated Fibroblast, Pre metastatic Niche, Cancer Associated Fibroblast

Abstract

Metastases of a tumour suggests poor prognosis and still treatment strategies against metastatic tumours are inadequate. Its resistance against existing therapeutic agents makes metastatic tumour treatment still challenging. Numerous research work has been done on cancer associated fibroblast (CAF), evidently suggesting of its contribution towards tumour metastasis. Recently a different stromal fibroblast seen in the metastatic sites, characteristically different from CAF known as metastatic associated fibroblast (MAF) has caught attention. Emergent preclinical studies propose that MAF targeting can ease therapeutic resistance and arrest progression of metastatic growth. This review discusses the current knowledge on this novel cell population that may bear on further understanding on the metastatic process.

Author Biographies

  • Subramania Iyer, Prof &Head of Dept, Head and Neck Oncology, Amrita Vishwa Vidyapeetham, Amrita Institute of Medical Sciences Kochi, India.

    Subramania Iyer, Prof &Head of Dept, Head and Neck Oncology, Amrita Vishwa Vidyapeetham, Amrita Institute of Medical Sciences Kochi, India.

  • Rajalakshmi G, DHR Fellow/Scientist Head and Neck Oncology, Amrita Vishwa Vidyapeetham, Amrita Institute of Medical Sciences Kochi, India.

    Rajalakshmi G, DHR Fellow/Scientist Head and Neck Oncology, Amrita Vishwa Vidyapeetham, Amrita Institute of Medical Sciences Kochi, India.

  • Mahija Janardhanan, Professor, Dept of Oral Pathology Amrita Vishwa Vidyapeetham, Amrita School of Dentistry Kochi, India.

    Mahija Janardhanan, Professor, Dept of Oral Pathology Amrita Vishwa Vidyapeetham, Amrita School of Dentistry Kochi, India.

  • Krishna Kumar Thankappan, Professor, Head and Neck Oncology, Amrita Vishwa Vidyapeetham, Amrita Institute of Medical Sciences Kochi, India.

     Krishna Kumar Thankappan, Professor, Head and Neck Oncology, Amrita Vishwa Vidyapeetham, Amrita Institute of Medical Sciences Kochi, India.

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Published

2024-11-30

Issue

Vol. 6 No. 6 (2024): Volume 6 Issue 6

Section

Articles