An Unusual Case of Anaplastic Oligodendroglioma with Extensive Calcifications and IDH1 R132H Mutation in a Young Male from Pakistan: A Comprehensive Clinicopathologic Report

Abstract

Oligodendrogliomas are diffuse gliomas defined by IDH mutation and 1p/19q codeletion, typically associated with favorable prognosis compared to astrocytic tumors. We report a unique case of a 37-year-old Pakistani male presenting with new-onset seizures, found to have an anaplastic oligodendroglioma with unusually extensive calcifications on neuroimaging. Diagnosis was confirmed by histopathology, immunohistochemistry, and molecular testing. This case underscores the importance of integrating radiologic, histologic, and molecular data, and highlights the need for documentation of such cases from South Asia, where published reports remain limited.