Diabetic Ketoacidosis and Diabetes Mellitus Caused by Trazodone: A Rare Case Report

Abstract

We describe a 28-year-old male with a history of schizophrenia who developed diabetic ketoacidosis and diabetes mellitus within 3 months after starting on trazodone to replace aripiprazole, and then the hyperglycemia and hemoglobin A1c level regained normal levels within 3 months after trazodone was stopped. To our knowledge, this is the first ever report on trazodone causing hyperglycemia. We therefore suggest checking blood glucose level before and after prescribing trazodone. Trazodone should be discontinued when hyperglycemia is detected, and alternative medication than trazodone should be considered for patients with diabetic history