Authors
-
Nanditha Chandran
Associate Professor, Department of Periodontics and Implantology, Mahe Institute of Dental Sciences and Hospital, Mahe, Puducherry, India
Author
-
Arjun MR
Associate Professor, Department of Periodontics and Implantology, Mahe Institute of Dental Sciences and Hospital, Mahe, Puducherry, India
Author
-
Jilu Jessy Abraham
Associate Professor, Department of Periodontics and Implantology, Mahe Institute of Dental Sciences and Hospital, Mahe, Puducherry, India
Author
-
Priyadharrshini C
Final year student, Department of Periodontics and Implantology, Mahe Institute of Dental Sciences and Hospital, Mahe, Puducherry, India
Author
-
Kaviyapriya S
Final year student, Department of Periodontics and Implantology, Mahe Institute of Dental Sciences and Hospital, Mahe, Puducherry, India
Author
Keywords:
Sub Antimicrobial Dose Doxycycline, Host Modulation, Periodontitis
Abstract
Periodontitis is a serious gum infection characterized by inflammation, followed by the destruction of the supporting structures of the tooth, including bone loss. Etiology of Periodontal disease is multifactorial which involves the role of host immunoinflammatory response and bacterial virulence factors. Host modulation therapy aims at downregulating or altering the destructive aspects of host response. Subantimicrobial Dose Doxycycline (SDD) is one such host modulatory agent that exerts its effects primarily through the inhibition of matrix metalloproteinases (MMPs) enzymes responsible for the degradation of extracellular matrix components, such as collagen, within the periodontal tissues. SDD is given as an adjunct to scaling and root planning. The present review focuses on SDD, its mechanism of action and application in host modulation therapy
Author Biographies
-
Nanditha Chandran, Associate Professor, Department of Periodontics and Implantology, Mahe Institute of Dental Sciences and Hospital, Mahe, Puducherry, India
Nanditha Chandran, Associate Professor, Department of Periodontics and Implantology, Mahe Institute of Dental Sciences and Hospital, Mahe, Puducherry, India.
-
Arjun MR, Associate Professor, Department of Periodontics and Implantology, Mahe Institute of Dental Sciences and Hospital, Mahe, Puducherry, India
Associate Professor, Department of Periodontics and Implantology, Mahe Institute of Dental Sciences and Hospital, Mahe, Puducherry, India.
-
Jilu Jessy Abraham, Associate Professor, Department of Periodontics and Implantology, Mahe Institute of Dental Sciences and Hospital, Mahe, Puducherry, India
Associate Professor, Department of Periodontics and Implantology, Mahe Institute of Dental Sciences and Hospital, Mahe, Puducherry, India.
-
Priyadharrshini C, Final year student, Department of Periodontics and Implantology, Mahe Institute of Dental Sciences and Hospital, Mahe, Puducherry, India
Final year student, Department of Periodontics and Implantology, Mahe Institute of Dental Sciences and Hospital, Mahe, Puducherry, India.
-
Kaviyapriya S, Final year student, Department of Periodontics and Implantology, Mahe Institute of Dental Sciences and Hospital, Mahe, Puducherry, India
Final year student, Department of Periodontics and Implantology, Mahe Institute of Dental Sciences and Hospital, Mahe, Puducherry, India.
