Evaluation of Antioxidants and Serum Immunoglobulins in YoungAdult Females with Striae Distensae
DOI:
https://doi.org/10.47363/JDMRS/2023(4)164Keywords:
Antioxidants, Serum Immunoglobulins, FemalesAbstract
ABSTRACT
Objective: Striae distensae constitute linear dermal scars that are accompanied by epidermal atrophy not yet associated with any significant medical problem, but can cause significant distress to its sufferers. The study aimed to analyze the relationship between antioxidants and total antioxidant capacity and Striae distensae in young female adults.
Materials and Methods: Using a random sampling technique, sixty (60) young adult females with Striae distensae (test samples) were selected and agematched with sixty (60) young adult females without Striae distensae, who served as the control group. Ten milliliters (10ml) of venous blood was collected from each participant, it was dispensed into plain containers and was allowed to cloth, and then centrifuged to obtain serum, which was stored at -20℃ before use. The antioxidant effect of the samples was studied using ABTS (2, 2,-azino-bis-3-ethyl benthiazoline-6-sulphonic acid) radical; cation decolorization assay. While the immunoglobulins were determined using the Elisa technique, data obtained were subjected to statistical analysis using SPSS 21, and the
P<0.05 level of significance was adopted.
Results: The results reveal significantly lower serum levels of GPx(0.1588±0.0264), Catalase(0.4627±0.2608), TAC (10.12±2.186) and SOD (0.8897±0.20708) in young adult females with SD compared to controls with GPx (0.1819±0.474), Catalase (0.6535±0.3112), TAC (11.82±2.991) and SOD (1.0389±0.1994). There are also non-significant correlation of GPx with IgG (r = 0.054, p = 0.684), IgE (r = -0.189, p = 0.148) and IgM (r = 0.058, p = 0.661) as well as there are non-significant correlation of serum SOD with IgG (r = -0.221, p = 0.089), IgE (r = 0.018, p = 0.891) and IgM (r = 0.088, p = 0.504) in young adult females with SD. The results also reveal non-significant correlation of TAC with IgG (r = -0.143, p = 0.275), and IgM (r = -0.071, p = 0.589), IgE (r = 0.180, p = 0.170) and non-significant positive correlation of Catalase with IgG (r = 0.168, p = 0.200) and IgE (r = 0.062, p = 0.637), IgM (r = -0.147, p = 0.262) in young adult females with SD.
Conclusion: This study concludes that Striae distensae is associated with reduced activities of enzymatic antioxidants in young adult females.
