Autoimmune Syndrome Induced by Adjuvants and Breast ImplantAssociated Anaplastic Large Cell Lymphoma: An Analysis

Abstract

The Adjuvant-Induced Autoimmune/Inflammatory Syndrome is caused by humoral mediators that lead to capsular contracture and fibrosis by the oxidation that occurs in the silicone. Anaplastic Large Cell Lymphoma occurs through the development of a seroma, with the formation of periprosthetic effusion or by an infiltration of the pathology itself, causing a tumoral growth inside and outside the capsule. The development of lymphoma occurs through the formation of a subclinical biofilm, capsular contracture, recurrent trauma, genetic predisposition or autoimmune etiology. To analyze these affections, a literature review was carried out on the symptomatology and pathophysiology of the Adjuvant-Induced Autoimmune/Inflammatory Syndrome and Anaplastic Large Cell
Lymphoma, which was searched using the terms “ASIA breast silicone” “Lymphoma” “Adjuvants” “Immunologic” “Breast Implants” in the platform PubMed. Analyzing the data obtained, it was noted that the symptoms of Adjuvant-Induced Autoimmune/Inflammatory Syndrome are nonspecific, such as fatigue, neurasthenia, myalgia, arthralgia, morning stiffness and night sweats, and, therefore, need attention. On the other hand, Anaplastic Large Cell Lymphoma presents with breast pain, periprosthetic effusion, palpable mass, among others. In view of these aspects, it is concluded that a good investigation must be
carried out when nonspecific symptoms appear, regardless of the time the surgery was performed, since these complications can appear years after the surgery