Effect of Combined Ethanol Leaf Extracts of Vernonia Amygdalina(Bitter Leave) and Gongronema Latifolium (Utazi) on Lead Induced Hepatoxicity in Wistar Rats

Authors

  • Mbah Chikodili Adolphus Department of Anatomy, Faculty of Basic Medical Sciences, David Umahi Federal University of Health Sciences, Ebonyi State, Nigeria Author
  • Ofoego Uzozie Chikere Department of Anatomy, Faculty of Basic Medical Sciences, Nnamdi Azikiwe University Awka, Nnewi Campus, Anambra State, Nigeria Author
  • Odo Jude Emeka Department of Humanities, School of General Studies, State University of Medical and Applied Sciences Igbo-Eno, Enugu State, Nigeria Author
  • Oyate Godwin Bernard Department of Nursing, Faculty of Nursing Sciences, David Umahi Federal University of Health Sciences, Ebonyi State, Nigeria Author

DOI:

https://doi.org/10.47363/JGHR/2025(6)183

Keywords:

Gongronema Latifolium , Wistar rats, Vernonia amygdalina

Abstract

This study evaluated the effect of leaf extract of Vernonia Amygdalina and Gongronema Latifolium on the liver of lead-induced toxicity wistar rats. A total of thirty (30) albino wistar rats were used for this study. Five (5) albino wistar rats were used for acute toxicity of the leave extracts of Vernonia Amygdalina andGongronema latifolium; while the remaining 25 albino wistar rats were divided into 5 groups: Group 1 which served as normal control received only water. Group 2 (NC) negative control received only lead. Group 3 (PC) positive control received lead + Vit. C. (standard drug for lead) via oral administration. Group 4: animals received lead + ethanol fraction of Vernonia Amygdalina and Gongronema Latifolium through oral administration (200 mg/Kg)/. Group 5: animals received lead + ethanol fraction of Vernonia amygdalina and Gongronema Lafifolium via oral administration (400 Mg/Kg). The combined effect of Vernonia amygdalina and Gongronema Latifolium thus has protective and curative properties against lead-induced liver damage.

Author Biographies

  • Mbah Chikodili Adolphus, Department of Anatomy, Faculty of Basic Medical Sciences, David Umahi Federal University of Health Sciences, Ebonyi State, Nigeria

    Department of Anatomy, Faculty of Basic Medical Sciences, David Umahi Federal University of Health Sciences, Ebonyi State, Nigeria 

  • Ofoego Uzozie Chikere, Department of Anatomy, Faculty of Basic Medical Sciences, Nnamdi Azikiwe University Awka, Nnewi Campus, Anambra State, Nigeria


    Department of Anatomy, Faculty of Basic Medical Sciences, Nnamdi Azikiwe University Awka, Nnewi Campus, Anambra State, Nigeria 

  • Odo Jude Emeka, Department of Humanities, School of General Studies, State University of Medical and Applied Sciences Igbo-Eno, Enugu State, Nigeria

    Department of Humanities, School of General Studies, State University of Medical and Applied Sciences Igbo-Eno, Enugu State, Nigeria

  • Oyate Godwin Bernard, Department of Nursing, Faculty of Nursing Sciences, David Umahi Federal University of Health Sciences, Ebonyi State, Nigeria


    Department of Nursing, Faculty of Nursing Sciences, David Umahi Federal University of Health Sciences, Ebonyi State, Nigeria

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Published

2025-11-20

Issue

Vol. 6 No. 6 (2025): Volume 6 Issue 6

Section

Articles