Hypoxic Respiratory Failure Due to Three Hits: Pulmonary Embolism, Rasburicase-Induced Methaemoglobinaemia And Haemolytic Anaemia In A Patient with Previously UndiagnosedGlucose-6-Phosphate Dehydrogenase Deficiency

Authors

  • Adel Ekladious Associate Professor, Acute Medical Unit and General Medicine Department, Canberra Hospital, Canberra Health Services, Canberra, ACT, Australia. UWA Medical School, University of Western Australia, Perth, WA, Australia Author
  • Yi Tong Vincent Aw Acute Medical Unit and General Medicine Department, Canberra Hospital, Canberra Health Services, Canberra, ACT, Australia Author

DOI:

https://doi.org/10.47363/JIMRR/2023(2)124

Keywords:

Pulmonary, Glucose

Abstract

We present a 35-year-old male patient who developed hypoxic respiratory failure from three concurrent pathologies–acute pulmonary embolism, methemoglobinemia and oxidative haemolytic anaemia from previously undiagnosed glucose-6-phosphate dehydrogenase deficiency, precipitated by
rasburicase therapy for tumour lysis syndrome following chemotherapy for non-Hodgkin’s lymphoma. Hypoxia resolved upon treating all pathologies, highlighting the need to consider these rare differential diagnoses.

Author Biographies

  • Adel Ekladious, Associate Professor, Acute Medical Unit and General Medicine Department, Canberra Hospital, Canberra Health Services, Canberra, ACT, Australia. UWA Medical School, University of Western Australia, Perth, WA, Australia

    Associate Professor, Acute Medical Unit and General Medicine Department, Canberra Hospital, Canberra Health Services, Canberra, ACT, Australia. UWA Medical School, University of Western Australia, Perth, WA, Australia

  • Yi Tong Vincent Aw, Acute Medical Unit and General Medicine Department, Canberra Hospital, Canberra Health Services, Canberra, ACT, Australia

    Acute Medical Unit and General Medicine Department, Canberra Hospital, Canberra Health Services, Canberra, ACT, Australia

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Published

2023-08-16

Issue

Vol. 2 No. 3 (2023): Volume 2 Issue 3

Section

Articles