The Relationship Between Celiac Disease and Kidney Disease: Immunological, Endothelial and Pathophysiological Mechanisms With Clinical Implications

Authors

  • Tania Leme da Rocha Martinez Tania Leme da Rocha Martinez, Rua Comandante Ismael Guilherme, 358 -Jardim Lusitânia, 04031-120 - São Paulo-SP, Brazil. Author
  • Anita L R Saldanha Anita L R Saldanha, Nephrology Department, BP - A Beneficência Portuguesa de São Paulo, São Paulo, Brazil Author
  • Ana Paula Pantoja Margeotto Ana Paula Pantoja Margeotto, Nephrology Department, BP - A Beneficência Portuguesa de São Paulo, São Paulo, Brazil Author
  • André Luis Valera Gasparoto André Luis Valera Gasparoto, Intensive Care Unit, BP - A Beneficência Portuguesa de São Paulo, São Paulo, Brazil Author

DOI:

https://doi.org/10.47363/JIMRR/2026(5)168

Keywords:

Celiac Disease, IgA, Nephropathy, Gluten, Immune Disease

Abstract

Celiac disease is a systemic autoimmune disorder with growing recognition of extraintestinal involvement, including endothelial dysfunction and renal disease. Recent studies highlight a gut-vascular-renal axis driven by immune activation, oxidative stress, and cytokine signaling. This review integrates epidemiological, immunological, endothelial, and renal mechanisms, with emphasis on immunoglobulin A nephropathy and chronic kidney disease.

Author Biographies

  • Tania Leme da Rocha Martinez, Tania Leme da Rocha Martinez, Rua Comandante Ismael Guilherme, 358 -Jardim Lusitânia, 04031-120 - São Paulo-SP, Brazil.

    Nephrology Department, BP - A Beneficência Portuguesa de São Paulo, São Paulo, Brazil

  • Anita L R Saldanha, Anita L R Saldanha, Nephrology Department, BP - A Beneficência Portuguesa de São Paulo, São Paulo, Brazil

    Nephrology Department, BP - A Beneficência Portuguesa de São Paulo, São Paulo, Brazil

  • Ana Paula Pantoja Margeotto, Ana Paula Pantoja Margeotto, Nephrology Department, BP - A Beneficência Portuguesa de São Paulo, São Paulo, Brazil

    Nephrology Department, BP - A Beneficência Portuguesa de São Paulo, São Paulo, Brazil

  • André Luis Valera Gasparoto, André Luis Valera Gasparoto, Intensive Care Unit, BP - A Beneficência Portuguesa de São Paulo, São Paulo, Brazil

    Intensive Care Unit, BP - A Beneficência Portuguesa de São Paulo, São Paulo, Brazil

Published

2026-05-03

Issue

Vol. 5 No. 2 (2026): Volume 5 Issue 2

Section

Articles