Diagnosis of CNS Lesions by CSF

Authors

  • Frank Y Shan Departments of Anatomic Pathology, Neurosurgery, Baylor Scott & White Medical Center, College of Medicine, Texas A & M University 2401 South 31st Street, Temple, TX 70508,USA. Author
  • Carlos Tirado Departments of Anatomic Pathology. Author
  • Eduardo Castro Departments of Anatomic Pathology. Author
  • Xiaohiu Zhang Department of Pathology, Moffitt Cancer Center 12902 USF Magnolia Dr., Tampa, FL 33612, USA. Author
  • Maio maio Hou Department of Neurology, Shanghai Changhai Hospital 168 Changhai Road, Yangpu District. Shanghai 200433 People’s Republic of China. Author
  • Dongxia Feng Neurosurgery, Baylor Scott & White Medical Center, College of Medicine, Texas A & M University 2401 South 31st Street, Temple, TX 70508, USA. Author
  • Jason H Huang Neurosurgery, Baylor Scott & White Medical Center, College of Medicine, Texas A & M University 2401 South 31st Street, Temple, TX 70508,USA. Author
  • Xiao ying Bi Department of Neurology, Shanghai Changhai Hospital 168 Changhai Road, Yangpu District. Shanghai 200433 People’s Republic of China. Author

DOI:

https://doi.org/10.47363/JJCMR/2022(2)129

Keywords:

Central nervous system, Cerebrospinal fluid, Lumbar puncture, Circulating tumor, MicroRNA, circulating tumor cells, liquid based biopsy, Primary central nervous system lymphoma, Secondary central nervous lymphoma, quantitative reverse transcription PCR, glial fibrillary acidic protein, gliblastoma, Extracellular vesicles EVs myeloid differentiation primary response protein 88 MYD88, next generation sequencing, Florescent in situ hybridization, Biomarkers Mass Spectrometry

Abstract

CNS tumors include primary and metastatic neoplasms, which together account for about 1% of human body tumors. The fragile nature of brain and spinal cord parenchyma limits both diagnostic and therapeutic approaches. Fortunately, the recently developed liquid based biopsy (LBB) technique provide highly convenient, fast and less-invasive method to collect and test the potential biomarkers. Biomarkers derived from liquid biopsies can promptly reflect changes on the gene expression profile of tumors. Biomarker derived from tumor cells contain abundant genetic information, which may provide a strong basis for the diagnosis and the individualized treatment of brain tumor patients. CSF can be used as a resource of biomarkers, the sensitivity and specificity of CSF biomarkers of patients with brain tumor is typically higher than those detected in peripheral blood and other sources. This chapter reviews the current different biomarkers in CSF and their significance in brain tumor diagnosis and monitoring.
ISSN: 2755-0141
Volume

Author Biographies

  • Frank Y Shan, Departments of Anatomic Pathology, Neurosurgery, Baylor Scott & White Medical Center, College of Medicine, Texas A & M University 2401 South 31st Street, Temple, TX 70508,USA.

    Frank Y Shan, Departments of Anatomic Pathology, Neurosurgery, Baylor Scott & White Medical Center, College of Medicine, Texas A & M University 2401 South 31st Street, Temple, TX 70508,USA.

  • Carlos Tirado, Departments of Anatomic Pathology.

    Carlos Tirado, Departments of Anatomic Pathology.

  • Eduardo Castro, Departments of Anatomic Pathology.

    Eduardo Castro, Departments of Anatomic Pathology.

  • Xiaohiu Zhang, Department of Pathology, Moffitt Cancer Center 12902 USF Magnolia Dr., Tampa, FL 33612, USA.

    Xiaohiu Zhang, Department of Pathology, Moffitt Cancer Center 12902 USF Magnolia Dr., Tampa, FL 33612, USA.

  • Maio maio Hou, Department of Neurology, Shanghai Changhai Hospital 168 Changhai Road, Yangpu District. Shanghai 200433 People’s Republic of China.

    Maio maio Hou, Department of Neurology, Shanghai Changhai Hospital 168 Changhai Road, Yangpu District. Shanghai 200433 People’s Republic of China.

  • Dongxia Feng, Neurosurgery, Baylor Scott & White Medical Center, College of Medicine, Texas A & M University 2401 South 31st Street, Temple, TX 70508, USA.

    Dongxia Feng, Neurosurgery, Baylor Scott & White Medical Center, College of Medicine, Texas A & M University 2401 South 31st Street, Temple, TX 70508, USA.

  • Jason H Huang, Neurosurgery, Baylor Scott & White Medical Center, College of Medicine, Texas A & M University 2401 South 31st Street, Temple, TX 70508,USA.

    Jason H Huang, Neurosurgery, Baylor Scott & White Medical Center, College of Medicine, Texas A & M University 2401 South 31st Street, Temple, TX 70508,USA.

  • Xiao ying Bi, Department of Neurology, Shanghai Changhai Hospital 168 Changhai Road, Yangpu District. Shanghai 200433 People’s Republic of China.

    Xiao ying Bi, Department of Neurology, Shanghai Changhai Hospital 168 Changhai Road, Yangpu District. Shanghai 200433 People’s Republic of China.

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Published

2025-12-05

Issue

Vol. 2 No. 2 (2022): Volume 2 Issue 2

Section

Articles