Is it Feasible to Completely Prevent Diabetic Kidney Disease?

Authors

  • Usama AA Sharaf El Din Professor, Nephrology unit, Internal Medicine Department, School of Medicine, Cairo University, Egypt Author
  • Mona M Salem Professor, Endocrinology unit, Internal Medicine Department, School of Medicine, Cairo University, Egypt Author
  • Dina O Abdulazim Lecturer, Rheumatology and Rehabilitation Department, School of Medicine, Cairo University, Egypt Author

DOI:

https://doi.org/10.47363/JONE/2022(2)121

Keywords:

Type 1 DM , Type 2DM, Diabetic Kidney Disease, Heart Failure, Diabetic Nephropathy , Sodium Glucose Cotransporters-2 Inhibitors , SGLT2 Inhibitors , Empagliflozin, Canagliflozin , Dapagliflozin

Abstract

When SGLT2Is were first introduced as hypoglycemic agents during the year 2008, no body was aware about their protective action on the heart, kidney,
and retina of patients suffering type 2 diabetes mellitus (T2DM). SGLT2Is have revolutionized the treatment of T2DM patients with established or at risk for
diabetic kidney disease (DKD). When Dapagliflosin was studied in T2DM patients with estimated glomerular filtration rate [eGFR] >90 mL/min/1.73m2,
and normal urine albumin excretion, these cases were still susceptible to develop the renal end points. These results have raised the question about the ideal time to use SGLT2Is to completely abort the incidence of DKD. This review will try to answer this question.

Author Biographies

  • Usama AA Sharaf El Din, Professor, Nephrology unit, Internal Medicine Department, School of Medicine, Cairo University, Egypt

    Usama AA Sharaf El Din, 58th Abbas El Akkad St., Nasr City, Cairo, Egypt.

  • Mona M Salem, Professor, Endocrinology unit, Internal Medicine Department, School of Medicine, Cairo University, Egypt

    Professor, Endocrinology unit, Internal Medicine Department, School of Medicine, Cairo University, Egypt.

  • Dina O Abdulazim, Lecturer, Rheumatology and Rehabilitation Department, School of Medicine, Cairo University, Egypt

    Lecturer, Rheumatology and Rehabilitation Department, School of Medicine, Cairo University, Egypt.

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Published

2025-12-03

Issue

Vol. 2 No. 4 (2022): Volume 2 Issue 4

Section

Articles