Burden and Predictors of Chronic Kidney Disease in Developing Country

Authors

  • Meskelu Kidu Weldetensae Nephrology Unit, Department of Internal Medicine, School of Medicine, College of Health Sciences, Mekelle University, Tigray, Ethiopia Author
  • Migbnesh Geberemedhin Weldegebreial Nephrology Unit, Department of Internal Medicine, School of Medicine, College of Health Sciences, Mekelle University, Tigray, Ethiopia Author
  • Measho Gebreselassie Department of Health System, School of Public Health, College of Health Sciences, Mekelle University, Tigray, Ethiopia Author
  • Ephrem Berhe Nephrology Unit, Department of Internal Medicine, School of Medicine, College of Health Sciences, Mekelle University, Tigray, Ethiopia Author

DOI:

https://doi.org/10.47363/JONE/2022(2)123

Keywords:

Chronic Kidney Disease , Hypertension , Nephrotoxic Agents , Urinary Tract Infection

Abstract

Chronic Kidney Disease (CKD) is being recognized as a global public health problem. It is a major non-communicable disease with the global prevalence varying between 10.5% and 13.1%. Diabetes and hypertension appear to be the leading causes of chronic kidney disease worldwide.

An institution based cross-sectional study was undertaken from Oct 20, 2018 to Nov 20, 2019 G.C. Data was collected using a pre-tested questionnaire designed to meet the study objective. After describing variables, logistic regression was conducted to identify independent associated factors of CKD. Statistical significance was declared at P<0.05.

Of the 450 studied patients, 260(57.8%) were males and more than half (54.2%) were between ages of 25 to 40 years. The prevalence of CKD among patients admitted to medical ward was 17.3% (95% CI 13 - 29.9) and 14.4% (95 % CI 6.2 – 12.3) by Cockcroft Gault and MDRD equations, respectively and majority (61.5%) of them were stage 5. Hypertension (AOR= 7.8 95%CI 4.1, 14.9), history of recurrent urinary tract infection (AOR= 3.5 95% CI 1.1, 7.3) and history of using nephrotoxic drugs (AOR=3.4 95% CI 2, 9.3) were significantly associated with CKD.

The burden of CKD among patients in a medical inpatient unit was high and majority of the patients present late. Hypertension, use of nephrotoxic agents and recurrent urinary tract infections were found to be important predictors.

Author Biographies

  • Meskelu Kidu Weldetensae, Nephrology Unit, Department of Internal Medicine, School of Medicine, College of Health Sciences, Mekelle University, Tigray, Ethiopia

    Meskelu Kidu Weldetensae, Nephrology Unit, Department of Internal Medicine, School of Medicine, College of Health Sciences, Mekelle University, Tigray, Ethiopia.

  • Migbnesh Geberemedhin Weldegebreial, Nephrology Unit, Department of Internal Medicine, School of Medicine, College of Health Sciences, Mekelle University, Tigray, Ethiopia

    Nephrology Unit, Department of Internal Medicine, School of Medicine, College of Health Sciences, Mekelle University, Tigray, Ethiopia.

  • Measho Gebreselassie, Department of Health System, School of Public Health, College of Health Sciences, Mekelle University, Tigray, Ethiopia

    Department of Health System, School of Public Health, College of Health Sciences, Mekelle University, Tigray, Ethiopia.

  • Ephrem Berhe, Nephrology Unit, Department of Internal Medicine, School of Medicine, College of Health Sciences, Mekelle University, Tigray, Ethiopia

    Nephrology Unit, Department of Internal Medicine, School of Medicine, College of Health Sciences, Mekelle University, Tigray, Ethiopia.

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Published

2025-12-03

Issue

Vol. 2 No. 4 (2022): Volume 2 Issue 4

Section

Articles