Does Simultaneous Intensity Modulated Radiotherapy with Temozolomide Increase the Radiosensitivity of Childhood Diffuse Intrinsic Pontine Glioma (DIPG)?- a Clinical Case from our Practice

Authors

  • Lena Marinova Medical Oncology Clinic, Department of Radiation Oncology and Metabolic Brachytherapy, UMHAT “Queen Joanna” Sofia, Bulgaria Author
  • Vaska Vasileva Medical Oncology Clinic, Department of Radiation Oncology and Metabolic Brachytherapy, UMHAT “Queen Joanna” Sofia, Bulgaria Author
  • Nikolay Kahchiev Medical Oncology Clinic, Department of Radiation Oncology and Metabolic Brachytherapy, UMHAT “Queen Joanna” Sofia, Bulgaria Author
  • Spaska Kovacheva- Damyanova Medical Oncology Clinic, Department of Radiation Oncology and Metabolic Brachytherapy, UMHAT “Queen Joanna” Sofia, Bulgaria Author

DOI:

https://doi.org/10.47363/JPRRR/2025(7)176

Keywords:

Diffuse Intrinsic Pontine Glioma, Childhood, Intensity Modulated Radiotherapy, Concomitant Temozolomide Radiotherapy, MRI

Abstract

Diffuse intrinsic pontine glioma (DIPG} is a high-grade glioma (HGG) that originates in the pons and is seen almost exclusively in children. The healing results achieved after a self -conducted conventional, hyperfractionated and hypofractionated radiotherapy (RT) up to a total tumor dose of 54 Gy at DIPG are unfavorable. We present our observations in a child with a locally advanced DIPG after a conventional concomitant Temozolomide radiotherapy. In order to increase the survival in this clinical case, we decided to conduct a simultaneous Temozolomide RT with an extended target volume with the inclusion of the ventricles. Two months after the Temozolomide intensity modulated radiotherapy (IMRT), the MRI reports a reduction in the tumor with a pronounced tumor necrosis, which is evidence of the radio -sensitization effect of Temosolomide.

Author Biographies

  • Lena Marinova, Medical Oncology Clinic, Department of Radiation Oncology and Metabolic Brachytherapy, UMHAT “Queen Joanna” Sofia, Bulgaria

    Medical Oncology Clinic, Department of Radiation Oncology and Metabolic Brachytherapy, UMHAT “Queen Joanna” Sofia, Bulgaria

  • Vaska Vasileva, Medical Oncology Clinic, Department of Radiation Oncology and Metabolic Brachytherapy, UMHAT “Queen Joanna” Sofia, Bulgaria

    Medical Oncology Clinic, Department of Radiation Oncology and Metabolic Brachytherapy, UMHAT “Queen Joanna” Sofia, Bulgaria

  • Nikolay Kahchiev, Medical Oncology Clinic, Department of Radiation Oncology and Metabolic Brachytherapy, UMHAT “Queen Joanna” Sofia, Bulgaria

    Medical Oncology Clinic, Department of Radiation Oncology and Metabolic Brachytherapy, UMHAT “Queen Joanna” Sofia, Bulgaria

  • Spaska Kovacheva- Damyanova, Medical Oncology Clinic, Department of Radiation Oncology and Metabolic Brachytherapy, UMHAT “Queen Joanna” Sofia, Bulgaria

    Medical Oncology Clinic, Department of Radiation Oncology and Metabolic Brachytherapy, UMHAT “Queen Joanna” Sofia, Bulgaria

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Published

2025-02-10

Issue

Vol. 7 No. 2 (2025): Volume 7 Issue 2

Section

Articles