Metabolic Differences in Monozygotic Twins: Evidence of Epigenetic Modulation in Lipid, Inflammatory and Hormonal Markers

Authors

  • Tania Leme da Rocha Martinez Nephrology Department, BP -A Beneficência Portuguesa de São Paulo, São Paulo, Rua Comandante Ismael Guilherme, 358 - Jardim Lusitânia, 04031-120 - São Paulo – SP, Brazil. Author
  • Abel Pereira Nephrology Department, BP - A Beneficência Portuguesa de São Paulo, São Paulo, Brazil Author
  • Anita LR Saldanha Nephrology Department, BP - A Beneficência Portuguesa de São Paulo, São Paulo, Brazil Author
  • Fernando Henrique Eduardo Guarnieri IESP-UERJ - Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil Author
  • Ana Paula Pantoja Margeotto Nephrology Department, BP - A Beneficência Portuguesa de São Paulo, São Paulo, Brazil Author
  • André Luis Valera Gasparoto Intensive Care Unit, BP - A Beneficência Portuguesa de São Paulo, São Paulo, Brazil Author

DOI:

https://doi.org/10.47363/JPRRR/2026(8)199

Keywords:

Twins, Homozygotic, Epigenetics, Environment, Genes

Abstract

Monozygotic twins share identical genomes but frequently present relevant phenotypic differences throughout development. Such differences have been
attributed to epigenetic mechanisms that modulate gene expression in response to environmental exposures. In this study, we analyzed 21 pairs (42
individuals) of monozygotic twins, evaluating intra-pair discrepancies in anthropometric, metabolic, hormonal, and lipid variables. After standardization, the largest differences were found in metabolic and lipid markers. The results strengthen the role of epigenetics in shaping phenotypic difference between genetically identical individuals.

Author Biographies

  • Tania Leme da Rocha Martinez, Nephrology Department, BP -A Beneficência Portuguesa de São Paulo, São Paulo, Rua Comandante Ismael Guilherme, 358 - Jardim Lusitânia, 04031-120 - São Paulo – SP, Brazil.

    Tania Leme da Rocha Martinez, Nephrology Department, BP -A Beneficência Portuguesa de São Paulo, São Paulo, Rua Comandante Ismael Guilherme, 358 - Jardim Lusitânia, 04031-120 - São Paulo – SP, Brazil.

  • Abel Pereira, Nephrology Department, BP - A Beneficência Portuguesa de São Paulo, São Paulo, Brazil

    Nephrology Department, BP - A Beneficência Portuguesa de São Paulo, São Paulo, Brazil

  • Anita LR Saldanha, Nephrology Department, BP - A Beneficência Portuguesa de São Paulo, São Paulo, Brazil

    Nephrology Department, BP - A Beneficência Portuguesa de São Paulo, São Paulo, Brazil

  • Fernando Henrique Eduardo Guarnieri, IESP-UERJ - Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil

    IESP-UERJ - Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil

  • Ana Paula Pantoja Margeotto, Nephrology Department, BP - A Beneficência Portuguesa de São Paulo, São Paulo, Brazil

    Nephrology Department, BP - A Beneficência Portuguesa de São Paulo, São Paulo, Brazil

  • André Luis Valera Gasparoto, Intensive Care Unit, BP - A Beneficência Portuguesa de São Paulo, São Paulo, Brazil

    Intensive Care Unit, BP - A Beneficência Portuguesa de São Paulo, São Paulo, Brazil

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Published

2026-06-22

Issue

Vol. 8 No. 6 (2026): Volume 8 Issue 6

Section

Articles