Beta-Endorphins in Autoimmune Diseases

Abstract

Beta-endorphin is an abundant endorphin synthesized and stored in the anterior pituitary gland and its µ receptors are present on immune cells and nervous system. Autoimmune diseases are increasing now days because of psychological stress induced release of stress releasing hormones such as cortisol, adrenaline, noradrenaline, ACTH activate inflammatory mediators from inflammatory cells leads to immune modulation mediated autoimmune diseases. Beta endorphins reduces psychological stress by releasing dopamine in the central nervous system by binding to its µ receptors situated on the nervous system.