Letter to the Editor: Advances and Challenges in Gastric Cancer Research
DOI:
https://doi.org/10.47363/JSAR/2025(6)224Keywords:
Gastric Cancer , nociceptive neurons, Digestive, Liver Diseases, CGRP - RAMP1 axis, Combined with Capecitabine and Oxaliplatin (CAPOX)Abstract
One of the significant recent findings is the discovery of the role of nociceptive neurons in gastric cancer progression. Timothy
C. Wang’s team from the Digestive and Liver Diseases Research Center at Columbia University in the US published a paper
in Nature in February 2025. They found that CGRP⁺ peptide - containing sensory neurons interact with gastric cancer cells
through the CGRP - RAMP1 axis. In multiple mouse gastric cancer models, these neurons expand significantly in a NGF -
TRK pathway - dependent manner. Activating these neurons promotes tumor growth and metastasis, while inhibition or ablation
has the opposite effect. In human gastric cancer samples, the density of CGRP⁺ nerves is higher, indicating its potential as a
new therapeutic target [1].