LIGHT/TNFSF14 in Cancer

Abstract

LIGHT/TNFSF14 is a member of the TNF superfamily and works as transmembrane and soluble forms. Different authors evaluated its role in cancer reaching different results. In detail, LIGHT has been described as having a dualistic role (anti-tumor or pro-tumor) in different tumors. In detail, inducing LIGHT expression in prostate and breast cancer in murine model a benefit is evident. It has been reported that higher LIGHT levels are related with a better prognosis in colorectal cancer liver metastases. In patients with glioma or glioblastoma high LIGHT levels are linked to a worsened
prognosis. While for patients with osteolytic non-small cell lung cancer, multiple myeloma, an increased pattern of LIGHT expression predicted the
active bone disease. In this review, the key role of LIGHT in glioma, glioblastoma, gastric, pancreatic, breast and prostate tumor, non-small cell lung cancer, chronic myeloid leukemia and multiple myeloma was described.