Associations of Wall Shear Stress on Vascular Morphology, Hemodynamics, and Many Clinical Variables

Abstract

Hemodynamics is generally considered as one of the most important factors in aneurysm rupture. Abnormal wall shear stress, greater pressure and flow impingement are all responsible for aneurysm rupture. The role of wall shear stress on intracranial aneurysms can be identified from its associations with other hemodynamics and related clinical variables, which is very little studied. The report aims to establish the relationship of wall shear stress with other hemodynamics and related clinical variables based on a real data set of 98 aneurysm subjects. It is derived herein that mean wall shear stress (WSS) is marginally positively associated with the subject’s diabetes history (DBH) (P<0.001), family history (FMH) (P<0.001), ELAPSS (P<0.001), and it is negatively associated with heart rate (HTR) (P<0.001) & PHASE (P<0.001). Mean WSS is negatively associated with the joint interaction effect (JIE) of age and mean velocity (VEL) i.e., AGE*VEL (P<0.001), JIE of maximum WSS (MXWS) and subject’s hypertension history (HPH) i.e., MXWS*HPH (P<0.001), JIE of MXWS and subject’s anatomical aneurysm’s location (LOC) i.e., MXWS*LOC (P<0.001), JIE of oscillatory shear index (OSI) and maximum pressure (MXPR) i.e. OSI*MXPR (P<0.001), mean WSS gradient (WSG) and mean velocity (VEL) i.e., WSG*VEL (P<0.001), while it is positively associated with the JIEs of mean wall pressure gradient (WPG) and systolic blood pressure (SBP) i.e., WPG*SBP (P<0.001), WPG and subject’s smoking history (SMH) i.e., WPG*SMH (P<0.001), OSI*SMH (P<0.001), MXPR*HYP (P<0.001), minimum WSS (MIWS) and subject’s alcohol consumption history (ACH) i.e., MIWS*ACH (P<0.001), and many more. These derived associations of WSS with other hemodynamics and related variables may be helpful for the aneurysm rupture treatment process.