The Study of Chemical and Biological Behaviour of Novel 2-Ammino-5-(Substituted)-1,3,4-Thiadiazole

Abstract

Due to biological and pharmacological properties, heterocyclic compounds and their derivatives have attracted strong interest in medicinal chemistry. The series of 2amino-5-(substituted phenyl)-1,3,4-thiadiazole was prepared in the laboratory via POCl3 -promoted cyclization reaction, and it is characterized by UV, FT-IR, and 1HNMR. Thiadiazoles have a heterocyclic nucleus that contains a five-member ring and nitrogen & sulfur. Thiadiazoleheterocyclic nucleus is an important class for new biologically active drug development. Thiadiazoles have unique chemical properties and biological characteristics. Thiadiazole & its derivatives have shown several pharmacological activities as antimicrobial, anti-inflammatory activity, antitubercular activity, antidiabetic activity, diuretic, antidepressant, and cytotoxic activity. Thiadiazole shows high energy against E. coli, gram-negative bacteria. It shows good antifungal activity against Aspergillus and Candida. However, the wide range of therapeutic values of 1,3,4-thiadiazole has encouraged us to do advanced research on it. This article is a review of the series of 2-amino-5-(substituted phenyl)-1,3,4thiadiazole.