Estimation of Tolnaftate in Pharmaceutical Preparations Samples

Abstract

A simple, accurate, precise, rapid, economical and sensitive ultraviolet spectrophotometric method has been developed for the determination of Tolnaftate in pharmaceutical preparations which shows maximum absorbance at 260 nm in distilled water. Beer’s law was obeyed in the range of 1 -14 μg/ ml ,with molar absorptivity of 2.183×104  L.mol-1.cm-1 , relative standard deviation of the method was less than 1.8%, and accuracy (average recovery %) was 100 ± 1.0. No interference was observed from common excipients and additives often accompany with Tolnaftate in pharmaceutical preparations .The method was successfully applied to the determination of Tolnaftate in some pharmaceutical formulations (creams and topical solutions) samples. The proposed method was validated by sensitivity and precision which proves suitability for the routine analysis of Tolnaftate in true samples.