The Research and Implications of Organoid Technology

Authors

  • Modesto Leite Rolim Neto School of Medicine, Federal University of Cariri – UFCA, Barbalha, Ceará, Brazil. Author
  • Maria Águeda Brito Leite Duarte School of Medicine, Juazeiro do Norte Medical School – FMJ/Estácio. Juazeiro do Norte, Ceará, Brazil. Author
  • Pablo de Oliveira Saraiva Bezerra School of Medicine, Juazeiro do Norte Medical School – FMJ/Estácio. Juazeiro do Norte, Ceará, Brazil. Author
  • Pablo de Oliveira Saraiva Bezerra School of Medicine, Juazeiro do Norte Medical School – FMJ/Estácio. Juazeiro do Norte, Ceará, Brazil. Author
  • Eugenia Machado Couto School of Medicine, Juazeiro do Norte Medical School – FMJ/Estácio. Juazeiro do Norte, Ceará, Brazil. Author
  • Juliana Oliveira Duarte Rebouças School of Medicine, Juazeiro do Norte Medical School – FMJ/Estácio. Juazeiro do Norte, Ceará, Brazil. Author
  • Dara Fernanda Brito Duarte School of Medicine, Juazeiro do Norte Medical School – FMJ/Estácio. Juazeiro do Norte, Ceará, Brazil. Author
  • Jaiany Rodrigues Libório School of Medicine, Juazeiro do Norte Medical School – FMJ/Estácio. Juazeiro do Norte, Ceará, Brazil. Author
  • Taysa Leite de Aquino School of Medicine, Juazeiro do Norte Medical School – FMJ/Estácio. Juazeiro do Norte, Ceará, Brazil. Author
  • Giovana Macedo Egídio Cavalcante School of Medicine, Juazeiro do Norte Medical School – FMJ/Estácio. Juazeiro do Norte, Ceará, Brazil. Author
  • Gabriela Macedo Egidio Cavalcante School of Medicine, Juazeiro do Norte Medical School – FMJ/Estácio. Juazeiro do Norte, Ceará, Brazil Author

DOI:

https://doi.org/10.47363/JJCMR/2021(1)121

Keywords:

Organoids, iPSC (Induced Pluripotent Stem Cells), Ethic, Diseases

Abstract

Background: The induction of the formation of organoids derived from induced pluripotent stem cells (iPSC) is a new technology that is being well studied and aims to improve the clinical condition of patients with various diseases and even patients undergoing certain types of procedures.

Methods: Systematic review, using the PRISMA protocol. The study period was from 2010 to 2020 and the keywords included “Organoids”, “iPSC”, “Ethic” and “Evidence-Based Medicine”, one at a timeand then combined with the Boolean operator “AND”.

Results: 44 registrations were found. Of this total, 15 articles were excluded because they have not approached organoids and stem cells objectively, often attending to other phenomena or details that are not of interest to the review.

Limitations: Discoveries about organoids and new methods to promote their generation and growth are constantly being tested and developed around the world, this implies a constant renewal of sources of information. The article was based on current and highly respected sources in the scientific community.

Conclusions: Organoids are unquestionably a technology capable of changing many concepts and guidelines in the medical environment. Faced with this enormous capacity, it is necessary that studies are constantly made and that the use of this new technology is widely discussed, since it addresses not only the scientific sphere, but also the ethical sphere, the social sphere. Improving this already existing technology so that it will increasingly mimic the human body is the challenge that exists and needs to be addressed by many professionals in different areas in harmony.

Author Biographies

  • Modesto Leite Rolim Neto, School of Medicine, Federal University of Cariri – UFCA, Barbalha, Ceará, Brazil.

    Modesto Leite Rolim Neto, 2School of Medicine, Federal University of Cariri – UFCA, Barbalha, Ceará, Brazil.

  • Maria Águeda Brito Leite Duarte, School of Medicine, Juazeiro do Norte Medical School – FMJ/Estácio. Juazeiro do Norte, Ceará, Brazil.

    Maria Águeda Brito Leite Duarte, School of Medicine, Juazeiro do Norte Medical School – FMJ/Estácio. Juazeiro do Norte, Ceará, Brazil.

  • Pablo de Oliveira Saraiva Bezerra, School of Medicine, Juazeiro do Norte Medical School – FMJ/Estácio. Juazeiro do Norte, Ceará, Brazil.

    Saraiva Bezerra, School of Medicine, Juazeiro do Norte Medical School – FMJ/Estácio. Juazeiro do Norte, Ceará, Brazil.

  • Pablo de Oliveira Saraiva Bezerra, School of Medicine, Juazeiro do Norte Medical School – FMJ/Estácio. Juazeiro do Norte, Ceará, Brazil.

    Pablo de Oliveira Saraiva Bezerra, School of Medicine, Juazeiro do Norte Medical School – FMJ/Estácio. Juazeiro do Norte, Ceará, Brazil.

  • Eugenia Machado Couto, School of Medicine, Juazeiro do Norte Medical School – FMJ/Estácio. Juazeiro do Norte, Ceará, Brazil.

    Eugenia Machado Couto, School of Medicine, Juazeiro do Norte Medical School – FMJ/Estácio. Juazeiro do Norte, Ceará, Brazil.

  • Juliana Oliveira Duarte Rebouças, School of Medicine, Juazeiro do Norte Medical School – FMJ/Estácio. Juazeiro do Norte, Ceará, Brazil.

    Juliana Oliveira Duarte Rebouças, School of Medicine, Juazeiro do Norte Medical School – FMJ/Estácio. Juazeiro do Norte, Ceará, Brazil.

  • Dara Fernanda Brito Duarte, School of Medicine, Juazeiro do Norte Medical School – FMJ/Estácio. Juazeiro do Norte, Ceará, Brazil.

    Dara Fernanda Brito Duarte, School of Medicine, Juazeiro do Norte Medical School – FMJ/Estácio. Juazeiro do Norte, Ceará, Brazil.

  • Jaiany Rodrigues Libório, School of Medicine, Juazeiro do Norte Medical School – FMJ/Estácio. Juazeiro do Norte, Ceará, Brazil.

    Jaiany Rodrigues Libório, School of Medicine, Juazeiro do Norte Medical School – FMJ/Estácio. Juazeiro do Norte, Ceará, Brazil.

  • Taysa Leite de Aquino, School of Medicine, Juazeiro do Norte Medical School – FMJ/Estácio. Juazeiro do Norte, Ceará, Brazil.

    Taysa Leite de Aquino, School of Medicine, Juazeiro do Norte Medical School – FMJ/Estácio. Juazeiro do Norte, Ceará, Brazil.

  • Giovana Macedo Egídio Cavalcante, School of Medicine, Juazeiro do Norte Medical School – FMJ/Estácio. Juazeiro do Norte, Ceará, Brazil.

    Giovana Macedo Egídio Cavalcante, School of Medicine, Juazeiro do Norte Medical School – FMJ/Estácio. Juazeiro do Norte, Ceará, Brazil.

  • Gabriela Macedo Egidio Cavalcante, School of Medicine, Juazeiro do Norte Medical School – FMJ/Estácio. Juazeiro do Norte, Ceará, Brazil

    Gabriela Macedo Egidio Cavalcante, School of Medicine, Juazeiro do Norte Medical School – FMJ/Estácio. Juazeiro do Norte, Ceará, Brazil.

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Published

2025-11-28

Issue

Vol. 1 No. 4 (2021): Volume 1 Issue 4

Section

Articles