DCs- IL2 Necessary for Glucocorticoids Which Necessary for Interferons Synthesis and Serotonin Synthesis then Promote Ang2-At2 and VEGF-A for Anti-Inflammatory Growth

Abstract

Dendritic cells (DCs) play an important role in improving and adapting immune responses, and development of chronic inflammation through producing Interleukin-2 which stimulate beta oxidation processes by OPA1 synthase for promoting both IFN-beta and GC-beta production followed by alpha oxidations for TLR4 and SIRPα1 production and for nucleocytosolic acetyl-CoA alpha production which considered as signature of a “growth specifically for anti-inflammatory growth.

Glucocorticoids and glutamine are the basic tools for increasing immune efficiency (regulated by OPA1 enzymes) and the main for regulating the adopted Interferons, that the deficiency in glucocorticoids synthesis and glutamine will suppress immune activities and will lead to deficiency in Interferons productions followed by decreasing in macrophages and T-cells functions. The formation of Glucocorticoid-gamma and IFN-gamma started by the effects of Cox2 on inflammatory sources followed by cytokine kinases production for IL2 synthesis upon synthetase functions followed by synthase for glucocorticoid-beta and IFN-beta productions which followed by phospholipase effect for producing PD-L1 synthesis which promote the progression of ovarian cancer.