Quantitative EEG Evidence of Functional Brain Recovery in Parkinson’s Disease Following Biophoton Therapy

Authors

  • James Z Liu First Institute of All Medicines, 139 Pittsburg Road, Butler, PA 16001, USA Author
  • Mariola A Smotrys First Institute of All Medicines, 139 Pittsburg Road, Butler, PA 16001, USA Author
  • Seth D Robinson Tesla BioHealing, Inc. 111 McCoy Street, Milford, DE 19963, USA Author
  • Hui X Yu Tesla BioHealing, Inc. 111 McCoy Street, Milford, DE 19963, USA Author
  • Sherry X Liu Tesla BioHealing, Inc. 111 McCoy Street, Milford, DE 19963, USA Author
  • Devin R Liu Tesla BioHealing, Inc. 111 McCoy Street, Milford, DE 19963, USA Author
  • Helen Y Gu First Institute of All Medicines, 139 Pittsburg Road, Butler, PA 16001, USA Author

DOI:

https://doi.org/10.47363/JNRRR/2025(7)225

Keywords:

Parkinson’s Disease, Biophoton Therapy, Quantitative EEG, Event-Related Potentials, Neuroplasticity, Non-Invasive Treatment

Abstract

Background: Parkinson’s disease (PD) is a progressive neurodegenerative disorder with limited treatment options that address both motor and non-motor symptoms. Biophoton therapy, a non-invasive modality emitting biologically coherent light, may offer a novel approach to restoring functional brain activity in PD patients by promoting cellular repair and neurophysiological rebalancing.

Methods: This study employed quantitative electroencephalography (qEEG) and event-related potential (ERP) biomarkers to assess the neurophysiological effects of biophoton therapy in multiple PD patients over a 4-week period. Each patient received continuous exposure to four strong biophoton generators. EEG metrics analyzed included posterior alpha peak frequency, theta/beta ratio, ERP latencies (P300, N2, P2, N4), reaction times, error rates, and brain region Z-scores associated with memory, attention, and motor control.

Results: Patients demonstrated measurable neurophysiological improvements after biophoton therapy compared to baseline and placebo periods. Key findings included reductions in posterior alpha frequency (indicative of decreased CNS hyperarousal), enhanced attention and vigilance (lowered theta/beta ratios), faster ERP latencies (e.g., P300 latency improved from 340 ms to 320 ms), and improved motor performance (reaction time decreased from 841 ms to 582 ms). Z-score analysis revealed normalization across Brodmann Areas 1–10, reflecting restored memory, impulse control, and emotional regulation. No significant improvements were observed during placebo conditions.

Conclusion: Strong biophoton generators produced consistent and clinically meaningful neurophysiological enhancements in Parkinson’s disease patients within a 4-week window. This therapy may represent a safe, non-pharmacologic, and scalable intervention capable of reversing functional markers of neurodegeneration. These results warrant larger controlled studies to confirm efficacy and explore underlying mechanisms.

Author Biographies

  • James Z Liu, First Institute of All Medicines, 139 Pittsburg Road, Butler, PA 16001, USA

    First Institute of All Medicines, 139 Pittsburg Road, Butler, PA 16001, USA

  • Mariola A Smotrys, First Institute of All Medicines, 139 Pittsburg Road, Butler, PA 16001, USA

    First Institute of All Medicines, 139 Pittsburg Road, Butler, PA 16001, USA

  • Seth D Robinson, Tesla BioHealing, Inc. 111 McCoy Street, Milford, DE 19963, USA

    Tesla BioHealing, Inc. 111 McCoy Street, Milford, DE 19963, USA

  • Hui X Yu, Tesla BioHealing, Inc. 111 McCoy Street, Milford, DE 19963, USA

    Tesla BioHealing, Inc. 111 McCoy Street, Milford, DE 19963, USA

  • Sherry X Liu, Tesla BioHealing, Inc. 111 McCoy Street, Milford, DE 19963, USA

    Tesla BioHealing, Inc. 111 McCoy Street, Milford, DE 19963, USA

  • Devin R Liu, Tesla BioHealing, Inc. 111 McCoy Street, Milford, DE 19963, USA

    Tesla BioHealing, Inc. 111 McCoy Street, Milford, DE 19963, USA

  • Helen Y Gu, First Institute of All Medicines, 139 Pittsburg Road, Butler, PA 16001, USA

    First Institute of All Medicines, 139 Pittsburg Road, Butler, PA 16001, USA

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Published

2025-07-25

Issue

Vol. 7 No. 7 (2025): Volume 7 Issue 7

Section

Articles