Evolution of the Drug Repurposing Paradigm

Authors

  • Igor Yu Malyshev Doctor of Medical Sciences, Head of the Department of Pathological Physiology of the Russian University of Medicine, Moscow, Russian Federation, Head of stress and adaptation laboratory of the Institute of General Pathology and Pathophysiology, Moscow, Russian Federation. Author
  • Shabunina EA Russian University of Medicine, Moscow, Russian Federation Author
  • Kuznetsova LV Russian University of Medicine, Moscow, Russian Federation Author
  • Lobanov EV Russian University of Medicine, Moscow, Russian Federation Author

DOI:

https://doi.org/10.47363/JPR/2024(6)169

Keywords:

Drugs, Repurposing, Therapy, Morphological Profiling

Abstract

The appearance of novel diseases like COVID-19, as well as the resistance of severe diseases to existing medications, have caused a need for new drugs to be developed quickly. The concept of drug repurposing has been offered to increase efficiency and minimise time and financial costs associated with drug development. Repurposing is a strategy for discovering new medical applications for already approved drugs. The study covers recent computational and experimental approaches for finding drug candidates for repurposing, as well as the challenges that arise along the way

Author Biographies

  • Igor Yu Malyshev, Doctor of Medical Sciences, Head of the Department of Pathological Physiology of the Russian University of Medicine, Moscow, Russian Federation, Head of stress and adaptation laboratory of the Institute of General Pathology and Pathophysiology, Moscow, Russian Federation.

    Igor Yu Malyshev, Doctor of Medical Sciences, Head of the Department of Pathological Physiology of the Russian University of Medicine, Moscow, Russian Federation, Head of stress and adaptation laboratory of the Institute of General Pathology and Pathophysiology, Moscow, Russian Federation. 

  • Shabunina EA, Russian University of Medicine, Moscow, Russian Federation

    Shabunina EA, Russian University of Medicine, Moscow, Russian Federation 

  • Kuznetsova LV, Russian University of Medicine, Moscow, Russian Federation

    Kuznetsova LV, Russian University of Medicine, Moscow, Russian Federation 

  • Lobanov EV, Russian University of Medicine, Moscow, Russian Federation

    Lobanov EV, Russian University of Medicine, Moscow, Russian Federation 

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Published

2025-12-02

Issue

Vol. 6 No. 2 (2024): Volume 6 Issue 2

Section

Articles