Relationship Between Clinical Symptoms Control, Oxidative Stress Status and Serum Vitamin D among Adults with Bronchial Asthma

Authors

  • Shehab M Abd El-Kader Department of Physical Therapy, Faculty of Medical Rehabilitation Sciences, King Abdulaziz University, P.O. Box 80324, Jeddah, 21589, Saudi Arabia. Author
  • Amany G Atiaa Department of General Surgery, burn and Dermatology, Faculty of Physical Therapy, Sinai University, Egypt. Author
  • Doha El-Sayed Ellakwa Department of Biochemistry and Molecular Biology, Faculty of Pharmacy for Girls, Al-Azhar University, Cairo, Egypt. Author
  • Salwa R El-Gendy Department of Physical Therapy, Faculty of Medical Rehabilitation Sciences, King Abdulaziz University, Kingdom of Saudi Arabia. Author
  • Mona M Abdelkhalek Department of Physical Therapy for Internal Medicine and Geriatrics, Badr University, Cairo, Egypt. Author
  • Samah Mahmoud Department of Physical Therapy for Cardiopulmonary and Geriatrics, Faculty of Physical Therapy, Cairo University, Egypt. Author
  • Shreen Hamed Department of Physical Therapy, Faculty of Medical Rehabilitation Sciences, King Abdulaziz University, Kingdom of Saudi Arabia. Author

DOI:

https://doi.org/10.47363/9jhf1q91

Keywords:

Asthma Control, Bronchial Asthma, Oxidative Stress, Vitamin D

Abstract

Background: The most common chronic lung disease in the world is bronchial asthma. Nonetheless, oxidative stress indicators have been linked to the onset of asthma in a number of recent investigations. However, vitamin D has a role in the pathogenesis of asthma.

Objective: The aim of this study was to determine the relationship between serum vitamin D levels, oxidative stress state, and clinical symptom control in individuals with bronchial asthma.

Material and Methods: The average age and Body Mass Index (BMI) of two hundred Saudi patients with bronchial asthma, both male and female, were 42.36 ± 6.24 years and 26.88 ± 2.95 kg/m2. Participants were chosen from Abassia Chest Hospital, Cairo, Egypt. The study excluded participants who were pregnant, smokers, had hepatitis, pulmonary failure, renal failure, or heart failure. Participants were divided into three groups according to their vitamin D levels.

Results: Malondialdehyde (MDA) mean values were significantly higher in the vitamin D deficiency group (A) than in the vitamin D insufficiency group (B) and the normal vitamin D group (C). Furthermore, compared to groups (B) and (C), group (A) had considerably lower serum levels of glutathione (GSH), glutathione peroxidase (GPx), superoxide dismutase (SOD), and the Asthma Control Test (ACT). Furthermore, in all three groups, vitamin D was
highly inversely connected with MDA levels (P<0.05) and directly correlated with levels of forced vital capacity (FVC), forced expiratory volume in one second (FEV1), Asthma Control Test (ACT), GPX, GSH, and SOD.

Conclusion: Vitamin D deficiency is associated with abnormal levels of oxidative stress biomarkers and the treatment of clinical symptoms in bronchial asthma patients.

Author Biographies

  • Shehab M Abd El-Kader, Department of Physical Therapy, Faculty of Medical Rehabilitation Sciences, King Abdulaziz University, P.O. Box 80324, Jeddah, 21589, Saudi Arabia.

    Shehab M Abd El-Kader, Department of Physical Therapy, Faculty of Medical Rehabilitation Sciences, King Abdulaziz University, P.O. Box 80324, Jeddah, 21589, Saudi Arabia.

  • Amany G Atiaa, Department of General Surgery, burn and Dermatology, Faculty of Physical Therapy, Sinai University, Egypt.

    Amany G Atiaa, Department of General Surgery, burn and Dermatology, Faculty of Physical Therapy, Sinai University, Egypt.

  • Doha El-Sayed Ellakwa, Department of Biochemistry and Molecular Biology, Faculty of Pharmacy for Girls, Al-Azhar University, Cairo, Egypt.

    Doha El-Sayed Ellakwa, Department of Biochemistry and Molecular Biology, Faculty of Pharmacy for Girls, Al-Azhar University, Cairo, Egypt.

  • Salwa R El-Gendy, Department of Physical Therapy, Faculty of Medical Rehabilitation Sciences, King Abdulaziz University, Kingdom of Saudi Arabia.

    Salwa R El-Gendy, Department of Physical Therapy, Faculty of Medical Rehabilitation Sciences, King Abdulaziz University, Kingdom of Saudi Arabia.

  • Mona M Abdelkhalek, Department of Physical Therapy for Internal Medicine and Geriatrics, Badr University, Cairo, Egypt.

    Mona M Abdelkhalek, Department of Physical Therapy for Internal Medicine and Geriatrics, Badr University, Cairo, Egypt.

  • Samah Mahmoud, Department of Physical Therapy for Cardiopulmonary and Geriatrics, Faculty of Physical Therapy, Cairo University, Egypt.

    Samah Mahmoud, Department of Physical Therapy for Cardiopulmonary and Geriatrics, Faculty of Physical Therapy, Cairo University, Egypt.

  • Shreen Hamed, Department of Physical Therapy, Faculty of Medical Rehabilitation Sciences, King Abdulaziz University, Kingdom of Saudi Arabia.

    Shreen Hamed, Department of Physical Therapy, Faculty of Medical Rehabilitation Sciences, King Abdulaziz University, Kingdom of Saudi Arabia.

Downloads

Published

2026-07-01

Issue

Vol. 8 No. 6 (2026): Volume 8 Issue 6

Section

Articles