Investigation of Regenerative Effects of Theranekron® and Misoprostol after Partial Hepatectomy in Rats

Authors

  • İsmet Yılmaz Department of Pharmacology, Faculty of Pharmacy, Inonu University, Malatya, Türkiye Author
  • Burhan Hakan Kanat Department of General Surgery, Faculty of Medicine, Malatya Turgut Özal University, Malatya, Türkiye Author
  • Azibe Yildiz Department of Histology-Embriology, Faculty of Medicine, Inonu University, Malatya, Türkiye Author
  • Yilmaz Bilgiç Department of Gastroenterology, Faculty of Medicine, Inonu University, Malatya, Türkiye Author
  • Ahmet Berk Department of Pharmacy, Elazığ Fethi Sekin City Hospital, Malatya, Türkiye Author
  • Ayşe Burçin Uyumlu Department of Biochemistry, Faculty of Pharmacy, Inonu University, Malatya, Türkiye Author
  • Muhammet Burak Açikgül Department of Pharmacology, Faculty of Pharmacy, Inonu University, Malatya, Türkiye Author

DOI:

https://doi.org/10.47363/JTMTR/2023(2)109

Keywords:

Regeneration, Theranekron, Misoprostol, Partial Hepatectomy, Rat

Abstract

In the present study we were aimed to investigate/compare regenerative effects of Theranekron® (TC) and Misoprostol (MS) after Partial Hepatectomy (PH) in rats. This study was conducted in 38 rats, they were divided in to 5 groups and 7 days study periot. When considering biochemical and histopathological results; we were seen that after PH 7 days duration was not sufficient and also at least 10 days periot may be necessary. Although some literatures were reported about positive effects of TC and MS on epithelial growing, we have not seen that they have not any positive effect on liver regeneration. In the future -at different doses and durations- these may be found effective.

Author Biographies

  • İsmet Yılmaz, Department of Pharmacology, Faculty of Pharmacy, Inonu University, Malatya, Türkiye

    Department of Pharmacology, Faculty of Pharmacy, Inonu University, Malatya, Türkiye

  • Burhan Hakan Kanat, Department of General Surgery, Faculty of Medicine, Malatya Turgut Özal University, Malatya, Türkiye

    Department of General Surgery, Faculty of Medicine, Malatya Turgut Özal University, Malatya, Türkiye

  • Azibe Yildiz, Department of Histology-Embriology, Faculty of Medicine, Inonu University, Malatya, Türkiye

    Department of Histology-Embriology, Faculty of Medicine, Inonu University, Malatya, Türkiye

  • Yilmaz Bilgiç, Department of Gastroenterology, Faculty of Medicine, Inonu University, Malatya, Türkiye

    Department of Gastroenterology, Faculty of Medicine, Inonu University, Malatya, Türkiye

  • Ahmet Berk, Department of Pharmacy, Elazığ Fethi Sekin City Hospital, Malatya, Türkiye

    Department of Pharmacy, Elazığ Fethi Sekin City Hospital, Malatya, Türkiye

  • Ayşe Burçin Uyumlu, Department of Biochemistry, Faculty of Pharmacy, Inonu University, Malatya, Türkiye

    Department of Biochemistry, Faculty of Pharmacy, Inonu University, Malatya, Türkiye

  • Muhammet Burak Açikgül, Department of Pharmacology, Faculty of Pharmacy, Inonu University, Malatya, Türkiye

    Department of Pharmacology, Faculty of Pharmacy, Inonu University, Malatya, Türkiye

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Published

2023-07-24

Issue

Vol. 2 No. 3 (2023): Volume 2 Issue 3

Section

Articles