Quantitative and Qualitative Structure Activity Relationship Study for Development of the Pet- Inhibitory Activity of 3-Nitro-2,4,6-Trihydroxy Benzamides

Abstract

The aim in this paper of these work present two components analyses quantitative and qualitative which consisted in the development and evaluation of the first component quantitative and structure activity relationships (QSAR) for the prediction In fact, various compounds inhibiting photosynthesis constitute the largest class of commercial herbicides. All of those inhibitors, including ureas, triazines, bis carbamates and phenols, interrupt photosynthetic electron transport (PET) by binding to quinine-binding protein (D1-protein). Various physicochemical descriptors were used in multiple linear regressions method (MLR) to develop the theoretical models, than using a cross-validation with leave-one-out method to optimize the model as well as possible to fit with the biological data, the most common approach used to study. The second quality of the compound compared with criteria for their power, these rules Lu Propose the four basic characteristics that Lipinski has identified.