Chromosome Gene, Hsl7 Gene in Vitro Studies

Abstract

Chromosome gene can expression many functions in human body. Eukaryotic cells are presence in yeast and human, in order to more understanding human gene, we use yeast as a model to research. The ORF (open reading frame) position of the Hsl7 gene is in yeast Saccharomyces YBR133C between 501804bp~504287bp of Chromosome II, with a total length of 2483bp, and the protein size is 95 kDa. Hsl7 gene is a methyltransferase. Protein-arginine N-methyltransferase involved in protein catabolism and regulation of the G2/M transition of mitosis; localizes to the septin collar of the bud neck, and the outer plaque of the spindle pole body in the G1 phase of the cell cycle (Saccharomyces Genome Database), Hsl7 (histone synthetic lethal 7) represent protein methylation, protein methylation is a type of post-translational modification that involves the addition of methyl groups to proteins, Protein methylation, including histone methylation and non-histone protein methylation, is one of the most important forms of posttranscriptional and epigenetic modifications.