The First Documented Case of Marchiafava-Bignami Disease with Concurrent Bilateral Deep Vein Thrombosis

Abstract

Marchiafava-Bignami Disease (MBD) presents as a rare neurological disease characterized by demyelination and necrosis in the corpus callosum. Most MBD cases are secondary to severe alcohol abuse and hypovitaminosis. MRI and other forms of neuroradiological imaging is necessary to confirm the diagnosis. We herein present an atypical case of a MBD and history of alcohol abuse who developed deep vein thrombosis in his bilateral lower extremities. This novel case represents the first documented report of MBD with concurrent DVT. Furthermore, we hypothesize that DVT may be a long-term complication associated with MBD.