Quantitative EEG Reveals Cognitive and Motor Restoration After Biophoton Treatment in Chronic Stroke

Authors

  • James Z Liu First Institute of All Medicines, 139 Pittsburg Road, Butler, PA 16001, USA Author
  • Mariola A Smotrys First Institute of All Medicines, 139 Pittsburg Road, Butler, PA 16001, USA Author
  • Seth D Robinson Tesla BioHealing, Inc. 111 McCoy Street, Milford, DE 19963, USA Author
  • Hui X Yu Tesla BioHealing, Inc. 111 McCoy Street, Milford, DE 19963, USA Author
  • Sherry X Liu Tesla BioHealing, Inc. 111 McCoy Street, Milford, DE 19963, USA Author
  • Devin R Liu Tesla BioHealing, Inc. 111 McCoy Street, Milford, DE 19963, USA Author
  • Helen Y Gu First Institute of All Medicines, 139 Pittsburg Road, Butler, PA 16001, USA Author

DOI:

https://doi.org/10.47363/JNRRR/2025(7)227

Keywords:

Chronic Stroke, Biophoton Therapy, Electroencephalography (EEG), Neuroplasticity, Event Related Potentials (ERP), Cognitive Rehabilitation

Abstract

Background: Chronic stroke is a leading cause of long-term neurological disability, with limited therapeutic options for restoring brain function beyond the acute recovery window. Recent advances in biophoton therapy suggest a novel approach to promote neuroplasticity through non-invasive, energybased mechanisms. This study aimed to evaluate the neurophysiological effects of strong biophoton generator therapy in patients with chronic stroke using quantitative EEG (qEEG) and behavioral metrics.

Methods: Five patients aged 63-77 years with confirmed chronic stroke received nightly exposure to four strong biophoton generators for 4 consecutive weeks. EEG recordings were acquired at baseline, Week 2, and Week 4 using the BrainView system. Primary outcomes included posterior alpha frequency, theta/beta ratio, frontal alpha asymmetry, and event-related potentials (P2, P3, P3b). Secondary outcomes included reaction time, error rate, and patient reported symptoms. EEG data were analyzed longitudinally to assess progressive neurofunctional change.

Results: Across patients, biophoton therapy was associated with increased posterior alpha frequency (mean +0.3–0.5 Hz), reduced theta/beta ratios (mean –0.05 to –0.1), and shortened P3 and P3b latencies (mean –16 to –20 ms), indicating enhanced cortical processing and attentional regulation. Behavioral improvements included reduced reaction time variability, fewer missed responses, and self-reported improvements in balance and strength. Placebo-treated control data showed no significant EEG or behavioral change.

Conclusion: Biophoton therapy may stimulate measurable recovery in chronic stroke patients, as reflected by improved EEG biomarkers and cognitive behavioral outcomes. These findings highlight the potential of bioenergetic interventions to activate latent neural plasticity, offering a promising nonpharmacological option for post-stroke rehabilitation.

Author Biographies

  • James Z Liu, First Institute of All Medicines, 139 Pittsburg Road, Butler, PA 16001, USA

    First Institute of All Medicines, 139 Pittsburg Road, Butler, PA 16001, USA

  • Mariola A Smotrys, First Institute of All Medicines, 139 Pittsburg Road, Butler, PA 16001, USA

    First Institute of All Medicines, 139 Pittsburg Road, Butler, PA 16001, USA

  • Seth D Robinson, Tesla BioHealing, Inc. 111 McCoy Street, Milford, DE 19963, USA

    Tesla BioHealing, Inc. 111 McCoy Street, Milford, DE 19963, USA

  • Hui X Yu, Tesla BioHealing, Inc. 111 McCoy Street, Milford, DE 19963, USA

    Tesla BioHealing, Inc. 111 McCoy Street, Milford, DE 19963, USA

  • Sherry X Liu, Tesla BioHealing, Inc. 111 McCoy Street, Milford, DE 19963, USA

    Tesla BioHealing, Inc. 111 McCoy Street, Milford, DE 19963, USA

  • Devin R Liu, Tesla BioHealing, Inc. 111 McCoy Street, Milford, DE 19963, USA

    Tesla BioHealing, Inc. 111 McCoy Street, Milford, DE 19963, USA

  • Helen Y Gu, First Institute of All Medicines, 139 Pittsburg Road, Butler, PA 16001, USA

    First Institute of All Medicines, 139 Pittsburg Road, Butler, PA 16001, USA

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Published

2025-08-01

Issue

Vol. 7 No. 8 (2025): Volume 7 Issue 8

Section

Articles