Biophoton Therapy Reverses Electrophysiological Deficits in Chronic Traumatic Brain Injury: Quantitative EEG Evidence of Cognitive and Network Recovery

Authors

  • James Z Liu First Institute of All Medicines, 139 Pittsburg Road, Butler, PA 16001, USA Author
  • Mariola A Smotrys First Institute of All Medicines, 139 Pittsburg Road, Butler, PA 16001, USA Author
  • Seth D Robinson Tesla BioHealing, Inc. 111 McCoy Street, Milford, DE 19963, USA Author
  • Hui X Yu Tesla BioHealing, Inc. 111 McCoy Street, Milford, DE 19963, USA Author
  • Sherry X Liu Tesla BioHealing, Inc. 111 McCoy Street, Milford, DE 19963, USA Author
  • Devin R Liu Tesla BioHealing, Inc. 111 McCoy Street, Milford, DE 19963, USA Author
  • Helen Y Gu First Institute of All Medicines, 139 Pittsburg Road, Butler, PA 16001, USA Author

DOI:

https://doi.org/10.47363/JNRRR/2025(7)228

Keywords:

Traumatic Brain Injury, Biophoton Therapy, Quantitative EEG, Neuromodulation, Cognitive Recovery, ERP Biomarkers

Abstract

Background: Chronic traumatic brain injury (TBI) is a debilitating condition lacking effective restorative treatments. Patients often experience persistent cognitive, emotional, and neurological impairments due to unresolved network-level dysfunction. Current therapeutic options provide limited recovery, underscoring the urgent need for novel neuromodulation strategies.

Objective: This study investigates the use of biophoton therapy a non-invasive, quantum-based light energy modality—as a novel intervention to improve brain function in chronic TBI patients using quantitative EEG (qEEG) and event-related potential (ERP) biomarkers.

Methods: Four patients with chronic TBI underwent resting-state EEG and ERP assessments at baseline, 2 weeks (placebo or early exposure), and 4 to 6 weeks following daily exposure to strong biophoton generators. EEG data were analyzed for changes in posterior alpha peak frequency, frontal theta/beta ratio, frontal alpha asymmetry, EC/EO alpha ratio, and Brodmann area Z-scores. ERP tasks evaluated visual/auditory processing and working memory.

Results: Placebo exposure produced no measurable change in cognitive or neural function. In contrast, biophoton therapy resulted in consistent electrophysiological improvements across patients, including: (1) Increased posterior alpha frequency (e.g., 9.4 → 10.4 Hz). (2) Reduced theta/beta ratios (e.g., 0.97 → 0.75), indicating improved attention. (3) Enhanced EC/EO alpha ratios, suggesting greater arousal regulation. (4) Decreased ERP latencies (e.g., N4 reduced by 48 ms), indicating faster working memory. (5) Normalization of Brodmann area z-scores in sensorimotor, frontal, and temporal regions.

Conclusion: Biophoton therapy represents a promising, drug-free intervention for restoring neurophysiological function in chronic TBI. This novel modality improves both cognitive performance and underlying brain network activity, as demonstrated by objective EEG biomarkers. These findings warrant further clinical investigation to establish biophoton therapy as a viable treatment pathway for unmet neurorehabilitation needs in TBI.

Author Biographies

  • James Z Liu, First Institute of All Medicines, 139 Pittsburg Road, Butler, PA 16001, USA

    First Institute of All Medicines, 139 Pittsburg Road, Butler, PA 16001, USA

  • Mariola A Smotrys, First Institute of All Medicines, 139 Pittsburg Road, Butler, PA 16001, USA

    First Institute of All Medicines, 139 Pittsburg Road, Butler, PA 16001, USA

  • Seth D Robinson, Tesla BioHealing, Inc. 111 McCoy Street, Milford, DE 19963, USA

    Tesla BioHealing, Inc. 111 McCoy Street, Milford, DE 19963, USA

  • Hui X Yu, Tesla BioHealing, Inc. 111 McCoy Street, Milford, DE 19963, USA

    Tesla BioHealing, Inc. 111 McCoy Street, Milford, DE 19963, USA

  • Sherry X Liu, Tesla BioHealing, Inc. 111 McCoy Street, Milford, DE 19963, USA

    Tesla BioHealing, Inc. 111 McCoy Street, Milford, DE 19963, USA

  • Devin R Liu, Tesla BioHealing, Inc. 111 McCoy Street, Milford, DE 19963, USA

    Tesla BioHealing, Inc. 111 McCoy Street, Milford, DE 19963, USA

  • Helen Y Gu, First Institute of All Medicines, 139 Pittsburg Road, Butler, PA 16001, USA

    First Institute of All Medicines, 139 Pittsburg Road, Butler, PA 16001, USA

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Published

2025-08-01

Issue

Vol. 7 No. 8 (2025): Volume 7 Issue 8

Section

Articles