Synthesis and Biological Activity of Monastroll

Abstract

Dihydropyrimidine-5-carboxylates are known to possess anti-hypertensive, anti-viral, anti-tumor, anti-staphylococcal, anti-cancer, etc. biological activity. The structure of dihydropyrimidines is of interest for studying the reactivity of a molecule and preparing new derivatives. In the specialized literature, a large number of different derivatives of dihydropyrimidine-5-carboxylates are described, however, most of them are obtained from the condensations of 1,3-dicarbonyl bonds with various aldehydes, urea or thiourea, catalyzed by different catalysts through different schemes of synthesis, which damages the finite yield.